Is it possible to change splash settings only of the second simulator?
Or can I animate splash settings, because I need at a later stage more splashes but not in the beginning.
When rendering cascade setup - you will have two meshes for each simulator while you can render them as is with no additional steps if you need to render a transparent liquid then you might see some artifacts when the two liquid meshes are overlapping.
This is why the setup in the video the two meshes are combined into one.
Yes you can change the splash settings for the second simulator, this should be fine and yes you can animate them