I’ve very happy to say that I think I found the problem. Now I can render the FastSSS at a Prepass rate of 1 almost as fast as a standard material.
tl;dr: when using FastSSS2, keep Adaptive DMC Image Sampler Max Subdivs low, like 4 or 8.
It appears that the Adaptive DMC Image Sampler “Max subdivs” value has a very significant effect on the speed of the FastSSS prepass. In my original tests, I was using Max subdivs of 50, which is way higher than necessary, and was left over from my tests with Nederhorst’s universal settings. However, having Max subdivs at this high value had no ill effects on my rendering with the standard material; it just required that I set the subdivs for each light, GI, specular, etc high enough to compensate for the division by 50 subdivs.
But I found that if I lowered Max subdivs to 8, or even better to the default of 4, which is all that is necessary for adequate anti-aliasing, the FastSSS prepass became immensely faster. Adjusting the “Single scatter subdivisions” value seemed to have no significant effect.
After I adjusted the subdivs of all the lights and specular and such down to match the division by 4 subdivs, it left my render time of the standard VRayMtl the same as it was before, but the calculation time of the FastSSS became probably over 40 times faster than the old tests, allowing me to increase the prepass to 1.
So a word of warning to people trying to use Nederhorst’s settings: he says in his Vray for Maya primer that he recommends setting Max subdivs all the way up to 100. This would cause a massive slowdown for FastSSS. I think it is best to use the Image Sampler only for anti-aliasing, not for cleaning up noise, and when it is used for this purpose alone, a Max subdivs in the range of 4 to 8 is adequate.
VRayMtl, rendertime = 1:06
VRayFastSSS2, Prepass rate = 1, rendertime = 1:16