I had this problem years ago and it seems that it is still not resolved. I have 2 GPUs - RTX 5090 and GTX 1080 Ti. I use the GTX 1080 Ti only for scene navigation and powering my 2 screens. When I choose to only use the RTX 5090 however, V-Ray still uses both GPUs for rendering. Please check the screenshots below. How do I tell V-Ray to not use my 2nd GPU (GTX 1080 Ti)?
UPDATE: I changed the render engine to Scanline and then back to V-Ray GPU and now the problem is gone. Let me know if you want me to send you the scene for debugging.


