VFB window turns black while rendering/IPR

On two machines we are encountering a very strange glitch: When we hit render the whole VFB window turns black - including GUI and all, not just the render area. When the render finishes it all comes back. IPRing is, obviously, not possible because of this (no visual feedback while rendering kind of defeats the purpose), which is pretty annoying. Any idea what could be causing this? When we delete all prefs it works for a couple of times and then we are back at square one…

Is by any chance the Viewport 2.0 setting in Windows>Preferences>Display set to OpenGL - Legacy for those workstations?