I’ve had this before, you using a hdri with a very strong small light source? Try blurring it a bit, making a bit more of a gap between the glass and object underneath and turn up the IR map settings. I dont know which one fixed it, I did all of those at once.
I assume all your materials are vray too, no weird maps in reflect/refract?
however i got rid of that after doing 2 things - i’ve removed hdr map that was (by mistake) mapped on one of my planes and unchecked sun visibility as samuel suggested.
When i finish rendering the scene i will go back one step and see what was causing the splotches… so i can post here again.
Are you by any chance using the Light Cache? If so, make sure the “use for glossy reflections/refractions” is turned off. I’ve noticed some terrible results, sometimes subtle, when looking through a glossy material using that. Otherwise the renderings are much faster. eh. you win some, you lose some.
if you have in the material change the color of the refract brighter than black or use an opacity map, you must turn affect shadows on. do you have it on?